4lnq: Difference between revisions

<StructureSection load='4lnq' size='340' side='right'caption='[[4lnq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[4lnq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LNQ FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lnq OCA], [https://pdbe.org/4lnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lnq RCSB], [https://www.ebi.ac.uk/pdbsum/4lnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lnq ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref>  

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Li H]]

[[Category: Wang Z-X]]

[[Category: Wu J-W]]