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==Crystal structure of Rhodostomin ARLDDL mutant== | ==Crystal structure of Rhodostomin ARLDDL mutant== | ||
<StructureSection load='3uci' size='340' side='right' caption='[[3uci]], [[Resolution|resolution]] 1.35Å' scene=''> | <StructureSection load='3uci' size='340' side='right'caption='[[3uci]], [[Resolution|resolution]] 1.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3uci]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3uci]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Agkistrodon_rhodostoma Agkistrodon rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UCI FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RHOD ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RHOD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8717 Agkistrodon rhodostoma])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uci OCA], [https://pdbe.org/3uci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uci RCSB], [https://www.ebi.ac.uk/pdbsum/3uci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uci ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH]] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). | ||
==See Also== | ==See Also== | ||
| Line 15: | Line 15: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Agkistrodon rhodostoma]] | [[Category: Agkistrodon rhodostoma]] | ||
[[Category: Large Structures]] | |||
[[Category: Chang, Y S]] | [[Category: Chang, Y S]] | ||
[[Category: Chang, Y T]] | [[Category: Chang, Y T]] | ||
Revision as of 09:07, 13 July 2022
Crystal structure of Rhodostomin ARLDDL mutantCrystal structure of Rhodostomin ARLDDL mutant
Structural highlights
Function[VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). See Also |
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