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==Structural Characterization of Inducible Nitric Oxide Synthase Substituted With Mesoheme==
==Structural Characterization of Inducible Nitric Oxide Synthase Substituted With Mesoheme==
<StructureSection load='4js9' size='340' side='right' caption='[[4js9]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
<StructureSection load='4js9' size='340' side='right'caption='[[4js9]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4js9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JS9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4js9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JS9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=MH0:MESOHEME'>MH0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=MH0:MESOHEME'>MH0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nod|1nod]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4js9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js9 OCA], [https://pdbe.org/4js9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4js9 RCSB], [https://www.ebi.ac.uk/pdbsum/4js9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4js9 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Inosl, Nos2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4js9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js9 OCA], [http://pdbe.org/4js9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4js9 RCSB], [http://www.ebi.ac.uk/pdbsum/4js9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4js9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>  
 
==See Also==
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Bolisetty, K]]
[[Category: Mus musculus]]
[[Category: Hannibal, L]]
[[Category: Bolisetty K]]
[[Category: Misra, S]]
[[Category: Hannibal L]]
[[Category: Page, R C]]
[[Category: Misra S]]
[[Category: Stuehr, D J]]
[[Category: Page RC]]
[[Category: Yu, Z]]
[[Category: Stuehr DJ]]
[[Category: Calmodulin-binding]]
[[Category: Yu Z]]
[[Category: Fad]]
[[Category: Fmn]]
[[Category: Iron]]
[[Category: Mesoheme]]
[[Category: Metal-binding]]
[[Category: Nadp]]
[[Category: Oxidoreductase]]

Revision as of 14:33, 24 November 2022

Structural Characterization of Inducible Nitric Oxide Synthase Substituted With MesohemeStructural Characterization of Inducible Nitric Oxide Synthase Substituted With Mesoheme

Structural highlights

4js9 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NOS2_MOUSE Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.[1]

See Also

References

  1. ↑ Kim SF, Huri DA, Snyder SH. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science. 2005 Dec 23;310(5756):1966-70. PMID:16373578 doi:http://dx.doi.org/10.1126/science.1119407

4js9, resolution 2.78Å

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