4dbu: Difference between revisions

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 ==Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3-((4 -(trifluoromethyl)phenyl)amino)benzoic acid==
-<StructureSection load='4dbu' size='340' side='right' caption='[[4dbu]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
+<StructureSection load='4dbu' size='340' side='right'caption='[[4dbu]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4dbu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DBU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4dbu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DBU FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BT9:3-{[4-(TRIFLUOROMETHYL)PHENYL]AMINO}BENZOIC+ACID'>BT9</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BT9:3-{[4-(TRIFLUOROMETHYL)PHENYL]AMINO}BENZOIC+ACID'>BT9</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dbs|4dbs]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dbu OCA], [https://pdbe.org/4dbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dbu RCSB], [https://www.ebi.ac.uk/pdbsum/4dbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dbu ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dbu OCA], [http://pdbe.org/4dbu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dbu RCSB], [http://www.ebi.ac.uk/pdbsum/4dbu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dbu ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
+[[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 27: / Line 25: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Chen, M]]
+[[Category: Large Structures]]
-[[Category: Christianson, D W]]
+[[Category: Chen M]]
-[[Category: Penning, T M]]
+[[Category: Christianson DW]]
-[[Category: Winkler, J D]]
+[[Category: Penning TM]]
-[[Category: Akr1c3 selective inhibitor]]
+[[Category: Winkler JD]]
-[[Category: Castrate resistant prostate cancer]]
-[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
-[[Category: Steroid metabolism]]
-[[Category: Tim barrel]]