4nr8: Difference between revisions
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
[[Category: Brennan, P]] | [[Category: Brennan, P]] | ||
[[Category: Delft, F | [[Category: Delft, F von]] | ||
[[Category: Edwards, A M]] | [[Category: Edwards, A M]] | ||
[[Category: Fedorov, O]] | [[Category: Fedorov, O]] | ||
Revision as of 09:48, 31 January 2018
Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligandCrystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand
Structural highlights
Disease[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2] Function[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). References
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