4e17: Difference between revisions

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 ==Alpha-E-catenin is an autoinhibited molecule that co-activates vinculin==
-<StructureSection load='4e17' size='340' side='right' caption='[[4e17]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='4e17' size='340' side='right'caption='[[4e17]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4e17]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E17 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E17 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4e17]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E17 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4e18|4e18]]</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e17 OCA], [https://pdbe.org/4e17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e17 RCSB], [https://www.ebi.ac.uk/pdbsum/4e17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e17 ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VCL, VINC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK]), Ctnna1, Catna1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e17 OCA], [http://pdbe.org/4e17 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e17 RCSB], [http://www.ebi.ac.uk/pdbsum/4e17 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e17 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/VINC_CHICK VINC_CHICK]] Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.<ref>PMID:15229287</ref> <ref>PMID:20584916</ref> <ref>PMID:20086044</ref>  [[http://www.uniprot.org/uniprot/CTNA1_MOUSE CTNA1_MOUSE]] Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.<ref>PMID:16325583</ref>
+[[https://www.uniprot.org/uniprot/VINC_CHICK VINC_CHICK]] Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.<ref>PMID:15229287</ref> <ref>PMID:20584916</ref> <ref>PMID:20086044</ref>
 ==See Also==
+*[[Catenin 3D structures|Catenin 3D structures]]
 *[[Vinculin|Vinculin]]
 == References ==
@@ Line 17: / Line 16: @@
 __TOC__
 </StructureSection>
-[[Category: Chick]]
+[[Category: Gallus gallus]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Large Structures]]
-[[Category: Bankston, L A]]
+[[Category: Mus musculus]]
-[[Category: Cadwell, G W]]
+[[Category: Bankston LA]]
-[[Category: Choi, H J]]
+[[Category: Cadwell GW]]
-[[Category: Liddington, R C]]
+[[Category: Choi H-J]]
-[[Category: Pokutta, S]]
+[[Category: Liddington RC]]
-[[Category: Weis, W I]]
+[[Category: Pokutta S]]
-[[Category: Cell adhesion]]
+[[Category: Weis WI]]
-[[Category: Four helix bundle]]