4jeu: Difference between revisions

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==Crystal Structure of Munc18a and Syntaxin1 with native N-terminus complex==
==Crystal Structure of Munc18a and Syntaxin1 with native N-terminus complex==
<StructureSection load='4jeu' size='340' side='right' caption='[[4jeu]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='4jeu' size='340' side='right'caption='[[4jeu]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jeu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JEU FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jeu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JEU FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jeh|4jeh]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jeu OCA], [https://pdbe.org/4jeu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jeu RCSB], [https://www.ebi.ac.uk/pdbsum/4jeu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jeu ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Stxbp1, Unc18a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Stx1a, Sap ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jeu OCA], [http://pdbe.org/4jeu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jeu RCSB], [http://www.ebi.ac.uk/pdbsum/4jeu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jeu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/STXB1_RAT STXB1_RAT]] May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. [[http://www.uniprot.org/uniprot/STX1A_RAT STX1A_RAT]] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.  
[https://www.uniprot.org/uniprot/STXB1_RAT STXB1_RAT] May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4jeu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4jeu" style="background-color:#fffaf0;"></div>
==See Also==
*[[Syntaxin 3D structures|Syntaxin 3D structures]]
*[[Syntaxin-binding protein|Syntaxin-binding protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Burkhardt, P]]
[[Category: Rattus norvegicus]]
[[Category: Colbert, K N]]
[[Category: Burkhardt P]]
[[Category: Fasshauer, D]]
[[Category: Colbert KN]]
[[Category: Hattendorf, D A]]
[[Category: Fasshauer D]]
[[Category: Weis, W I]]
[[Category: Hattendorf DA]]
[[Category: Weiss, T M]]
[[Category: Weis WI]]
[[Category: Endocytosis-exocytosis complex]]
[[Category: Weiss TM]]
[[Category: Membrane]]
[[Category: Neurotransmitter transport]]
[[Category: Phosphoprotein]]
[[Category: Protein complex]]
[[Category: Protein transport]]
[[Category: Transmembrane]]
[[Category: Transport]]

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