1at3: Difference between revisions
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[[Image:1at3.gif|left|200px]]<br /> | [[Image:1at3.gif|left|200px]]<br /><applet load="1at3" size="450" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1at3" size="450" color="white" frame="true" align="right" spinBox="true" | |||
caption="1at3, resolution 2.5Å" /> | caption="1at3, resolution 2.5Å" /> | ||
'''HERPES SIMPLEX VIRUS TYPE II PROTEASE'''<br /> | '''HERPES SIMPLEX VIRUS TYPE II PROTEASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1AT3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1] with DFP as [http://en.wikipedia.org/wiki/ligand ligand]. | 1AT3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1] with DFP as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=ACT:Novel Active Site Triad SER 129, HIS 61 And HIS 148'>ACT</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AT3 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: viral protease]] | [[Category: viral protease]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 14:21:07 2007'' | ||
Revision as of 15:11, 18 December 2007
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HERPES SIMPLEX VIRUS TYPE II PROTEASE
OverviewOverview
Human herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are, responsible for herpes labialis (cold sores) and genital herpes, respectively. They encode a serine protease that is required for viral, replication, and represent a viable target for therapeutic intervention., Here, we report the crystal structures of HSV-1 and HSV-2 proteases, the, latter in the presence and absence of the covalently bound transition, state analog inhibitor diisopropyl phosphate (DIP). The HSV-1 and HSV-2, protease structures show a fold that is neither like chymotrypsin nor like, subtilisin, and has been seen only in the recently determined, cytomegalovirus (CMV) and varicella-zoster virus (VZV) protease, structures. HSV-1 and HSV-2 proteases share high sequence homology and, have almost identical three-dimensional structures. However, structural, differences are observed with the less homologous CMV protease, offering a, structural basis for herpes virus protease ligand specificity. The bound, inhibitor identifies the oxyanion hole of these enzymes and defines the, active site cavity.
About this StructureAbout this Structure
1AT3 is a Single protein structure of sequence from Human herpesvirus 1 with DFP as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex., Hoog SS, Smith WW, Qiu X, Janson CA, Hellmig B, McQueney MS, O'Donnell K, O'Shannessy D, DiLella AG, Debouck C, Abdel-Meguid SS, Biochemistry. 1997 Nov 18;36(46):14023-9. PMID:9369473
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