1lhs: Difference between revisions

Revision as of 23:55, 2 May 2008

LOGGERHEAD SEA TURTLE MYOGLOBIN (AQUO-MET)

OverviewOverview

The X-ray crystal structures of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin have been determined at 2.0 A resolution (R = 0.182, and 0.178, respectively). The results here reported, representing the first reptile globin solved by X-ray crystallography, have been analyzed in parallel with data for related monomeric hemoproteins, and indicate a strong overall structural similarity between the loggerhead sea turtle and mammalian myoglobins, reflected by the 63% amino acid identity of their primary structures. The root-mean-square deviation between the entire polypeptide backbones of loggerhead sea turtle and sperm whale myoglobins, after structure superposition, is 0.83 A. Upon cyanide binding to the protein distal site, the iron-bound water molecule present in the aquo-met form is displaced by the incoming ligand. Cyanide is oriented towards the inner part of the heme distal site forming a Fe-C-N angle of 133 degrees.

About this StructureAbout this Structure

1LHS is a Single protein structure of sequence from Caretta caretta. Full crystallographic information is available from OCA.

ReferenceReference

Reptile heme protein structure: X-ray crystallographic study of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin at 2.0 A resolution., Nardini M, Tarricone C, Rizzi M, Lania A, Desideri A, De Sanctis G, Coletta M, Petruzzelli R, Ascenzi P, Coda A, et al., J Mol Biol. 1995 Mar 31;247(3):459-65. PMID:7714901 Page seeded by OCA on Fri May 2 23:55:57 2008

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OCA

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 '''LOGGERHEAD SEA TURTLE MYOGLOBIN (AQUO-MET)'''
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 [[Category: Sanctis, G De.]]
 [[Category: Tarricone, C.]]
-[[Category: oxygen storage]]
+[[Category: Oxygen storage]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:55:57 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:02:55 2008''