4n9d: Difference between revisions

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 ==Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)==
-<StructureSection load='4n9d' size='340' side='right' caption='[[4n9d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+<StructureSection load='4n9d' size='340' side='right'caption='[[4n9d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4n9d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N9D FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4n9d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9D FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2HJ:4-({[(4-TERT-BUTYLPHENYL)SULFONYL]AMINO}METHYL)-N-(PYRIDIN-3-YL)BENZAMIDE'>2HJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HJ:4-({[(4-TERT-BUTYLPHENYL)SULFONYL]AMINO}METHYL)-N-(PYRIDIN-3-YL)BENZAMIDE'>2HJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n9b|4n9b]], [[4n9c|4n9c]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9d OCA], [https://pdbe.org/4n9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9d RCSB], [https://www.ebi.ac.uk/pdbsum/4n9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9d ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NAMPT, PBEF, PBEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9d OCA], [http://pdbe.org/4n9d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n9d RCSB], [http://www.ebi.ac.uk/pdbsum/4n9d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9d ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
+[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 20: @@
 ==See Also==
-*[[Phosphoribosyltransferase|Phosphoribosyltransferase]]
+*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Nicotinamide phosphoribosyltransferase]]
+[[Category: Large Structures]]
-[[Category: Baumeister, T]]
+[[Category: Baumeister T]]
-[[Category: Bravo, B]]
+[[Category: Bravo B]]
-[[Category: Brien, T O]]
+[[Category: Dragovich PS]]
-[[Category: Dragovich, P S]]
+[[Category: Giannetti AM]]
-[[Category: Giannetti, A M]]
+[[Category: Ho Y]]
-[[Category: Ho, Y]]
+[[Category: Hua R]]
-[[Category: Hua, R]]
+[[Category: Li G]]
-[[Category: Li, G]]
+[[Category: Liang X]]
-[[Category: Liang, X]]
+[[Category: O'Brien T]]
-[[Category: Oh, A]]
+[[Category: Oh A]]
-[[Category: Skelton, N J]]
+[[Category: Skelton NJ]]
-[[Category: Wang, C]]
+[[Category: Wang C]]
-[[Category: Wang, W]]
+[[Category: Wang W]]
-[[Category: Wang, Y]]
+[[Category: Wang Y]]
-[[Category: Xiao, Y]]
+[[Category: Xiao Y]]
-[[Category: Yuen, P]]
+[[Category: Yuen P]]
-[[Category: Zak, M]]
+[[Category: Zak M]]
-[[Category: Zhao, G]]
+[[Category: Zhao G]]
-[[Category: Zhao, Q]]
+[[Category: Zhao Q]]
-[[Category: Zheng, X]]
+[[Category: Zheng X]]
-[[Category: Transferase-transferase inhibitor complex]]