3par: Difference between revisions
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==Surfactant Protein-A neck and carbohydrate recognition domain (NCRD) in the absence of ligand== | ==Surfactant Protein-A neck and carbohydrate recognition domain (NCRD) in the absence of ligand== | ||
<StructureSection load='3par' size='340' side='right' caption='[[3par]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='3par' size='340' side='right'caption='[[3par]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3par]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3par]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PAR FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r13|1r13]], [[1r14|1r14]], [[3pak|3pak]], [[3paq|3paq]], [[3pbf|3pbf]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1r13|1r13]], [[1r14|1r14]], [[3pak|3pak]], [[3paq|3paq]], [[3pbf|3pbf]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sftp-1, Sftp1, Sftpa, Sftpa1 ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sftp-1, Sftp1, Sftpa, Sftpa1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3par FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3par OCA], [https://pdbe.org/3par PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3par RCSB], [https://www.ebi.ac.uk/pdbsum/3par PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3par ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/SFTPA_RAT SFTPA_RAT]] In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Buffalo rat]] | [[Category: Buffalo rat]] | ||
[[Category: Large Structures]] | |||
[[Category: Cafarella, T M]] | [[Category: Cafarella, T M]] | ||
[[Category: Head, J]] | [[Category: Head, J]] | ||