1kq9: Difference between revisions

Revision as of 23:02, 2 May 2008

Human methionine aminopeptidase type II in complex with L-methionine

OverviewOverview

Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the molecular target of anti-angiogenic agents such as fumagillin and its analogues. We describe here the crystal structure of hMetAP-2 in complex with l-methionine and d-methionine at 1.9 and 2.0A resolution, respectively. The comparison of the structure of the two complexes establishes the basis of enantiomer discrimination and provides some considerations for the design of selective MetAP-2 inhibitors.

About this StructureAbout this Structure

1KQ9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Human methionine aminopeptidase type 2 in complex with L- and D-methionine., Nonato MC, Widom J, Clardy J, Bioorg Med Chem Lett. 2006 May 15;16(10):2580-3. Epub 2006 Mar 15. PMID:16540317 Page seeded by OCA on Fri May 2 23:02:24 2008

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OCA

@@ Line 1: / Line 1: @@
 [[Image:1kq9.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1kq9 |SIZE=350|CAPTION= <scene name='initialview01'>1kq9</scene>, resolution 1.90&Aring;
+The line below this paragraph, containing "STRUCTURE_1kq9", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1kq9|  PDB=1kq9  |  SCENE=  }}
-|RELATEDENTRY=[[1kq0|1KQ0]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kq9 OCA], [http://www.ebi.ac.uk/pdbsum/1kq9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kq9 RCSB]</span>
-}}
 '''Human methionine aminopeptidase type II in complex with L-methionine'''
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 [[Category: Nonato, M C.]]
 [[Category: Widom, J.]]
-[[Category: central b-sheet and two pairs of a-helice]]
+[[Category: Central b-sheet and two pairs of a-helice]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:02:24 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:52:01 2008''