3s1h: Difference between revisions

<StructureSection load='3s1h' size='340' side='right' caption='[[3s1h]], [[Resolution|resolution]] 1.75&Aring;' scene=''>

<table><tr><td colspan='2'>[[3s1h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S1H FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=56Z:4-{[4-AMINO-5-(4-METHOXYBENZOYL)-1,3-THIAZOL-2-YL]AMINO}BENZENESULFONAMIDE'>56Z</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ql8|3ql8]], [[3qqf|3qqf]], [[3qqg|3qqg]], [[3qqh|3qqh]], [[3qqj|3qqj]], [[3qqk|3qqk]], [[3qql|3qql]], [[3qrt|3qrt]], [[3qru|3qru]], [[3qtq|3qtq]], [[3qtr|3qtr]], [[3qts|3qts]], [[3qtu|3qtu]], [[3qtw|3qtw]], [[3qtx|3qtx]], [[3qtz|3qtz]], [[3qu0|3qu0]], [[3qwj|3qwj]], [[3qwk|3qwk]], [[3qx2|3qx2]], [[3qx4|3qx4]], [[3qxo|3qxo]], [[3qxp|3qxp]], [[3qzf|3qzf]], [[3qzg|3qzg]], [[3qzh|3qzh]], [[3qzi|3qzi]], [[3r1q|3r1q]], [[3r1s|3r1s]], [[3r1y|3r1y]], [[3r28|3r28]], [[3r6x|3r6x]], [[3r71|3r71]], [[3r73|3r73]], [[3r7e|3r7e]], [[3r7i|3r7i]], [[3r7u|3r7u]], [[3r7v|3r7v]], [[3r7y|3r7y]], [[3r83|3r83]], [[3r8l|3r8l]], [[3r8m|3r8m]], [[3r8p|3r8p]], [[3r8u|3r8u]], [[3r8v|3r8v]], [[3r8z|3r8z]], [[3r9d|3r9d]], [[3r9h|3r9h]], [[3r9n|3r9n]], [[3r9o|3r9o]], [[3rah|3rah]], [[3rai|3rai]], [[3rak|3rak]], [[3ral|3ral]], [[3rjc|3rjc]], [[3rk5|3rk5]], [[3rk7|3rk7]], [[3rk9|3rk9]], [[3rkb|3rkb]], [[3rm6|3rm6]], [[3rm7|3rm7]], [[3rmf|3rmf]], [[3rni|3rni]], [[3roy|3roy]], [[3rpo|3rpo]], [[3rpr|3rpr]], [[3rpv|3rpv]], [[3rpy|3rpy]], [[3rzb|3rzb]], [[3s00|3s00]], [[3s0o|3s0o]], [[3sqq|3sqq]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s1h OCA], [http://pdbe.org/3s1h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3s1h RCSB], [http://www.ebi.ac.uk/pdbsum/3s1h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3s1h ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>   

*[[Cyclin-dependent kinase|Cyclin-dependent kinase]]