1a8a: Difference between revisions
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[[Image:1a8a.gif|left|200px]]<br /> | [[Image:1a8a.gif|left|200px]]<br /><applet load="1a8a" size="450" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1a8a" size="450" color="white" frame="true" align="right" spinBox="true" | |||
caption="1a8a, resolution 1.9Å" /> | caption="1a8a, resolution 1.9Å" /> | ||
'''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE'''<br /> | '''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1A8A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA and GSE as [http://en.wikipedia.org/wiki/ligands ligands]. | 1A8A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA and GSE as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=GSE:Gse Binding Site (Includes 2 Ca Ions)'>GSE</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A8A OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: phospholipid analog]] | [[Category: phospholipid analog]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 14:10:44 2007'' | ||
Revision as of 15:00, 18 December 2007
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RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE
OverviewOverview
Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as, annexins, protein kinase C, and certain coagulation proteins. Crystal, structures of Ca(2+)-annexin V complexes with phospholipid polar heads, provide molecular details of 'Ca(2+)-bridges' as key features in the, membrane attachment exhibited by these proteins. Distinct binding sites, for phospholipid head groups are observed, including a novel, double-Ca2+, recognition site for phosphoserine that may serve as a phosphatidylserine, receptor site in vivo.
About this StructureAbout this Structure
1A8A is a Single protein structure of sequence from Rattus norvegicus with CA and GSE as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670
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