1kgc: Difference between revisions

Revision as of 22:42, 2 May 2008

Immune Receptor

OverviewOverview

Despite a potential repertoire of >10(15) alphabeta T cell receptors (TcR), the HLA B8-restricted cytolytic T cell response to a latent antigen of Epstein-Barr virus (EBV) is strikingly limited in the TcR sequences that are selected. Even in unrelated individuals this response is dominated by a single highly restricted TcR clonotype that selects identical combinations of hypervariable Valpha, Vbeta, D, J, and N region genes. We have determined the 1.5 A crystal structure of this "public" TcR, revealing that five of the six hypervariable loops adopt novel conformations providing a unique combining site that contains a deep pocket predicted to overlay the HLA B8-peptide complex. The findings suggest a structural basis for the immunodominance of this clonotype in the immune response to EBV.

About this StructureAbout this Structure

1KGC is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance., Kjer-Nielsen L, Clements CS, Brooks AG, Purcell AW, McCluskey J, Rossjohn J, Structure. 2002 Nov;10(11):1521-32. PMID:12429093 Page seeded by OCA on Fri May 2 22:42:49 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1kgc.gif|left|200px]]
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 '''Immune Receptor'''
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 [[Category: Purcell, A W.]]
 [[Category: Rossjohn, J.]]
-[[Category: lc13 clone]]
+[[Category: Lc13 clone]]
-[[Category: t-cell receptor]]
+[[Category: T-cell receptor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:42:49 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:48:12 2008''