Sandbox 148: Difference between revisions

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	== How does Kapβ2 identify its cargo? ==		== How does Kapβ2 identify its cargo? ==

	The NLS located on Kapβ2 cargos, are named the PY-NLS and they bind to the C-terminal arch of Kapβ2. The internal surface of kapβ2 superhelix at the C-terminal arch has negative electrostatic potential.		The NLS located on Kapβ2 cargos, are named the PY-NLS and they bind to the C-terminal arch of Kapβ2. The internal surface of kapβ2 superhelix at the C-terminal arch has negative electrostatic potential. the recognition of the PY-NLS by Kapβ2 follows certain guidelines: (1) PY-NLS, when not bound to Kapβ2, lacks a secondary structure; (2) PY-NLS has an overall positive charge allowing for electrostatic compatibility with Kapβ2; (3) the general sequence for PY-NLS is either a hydrophobic or a basic motif at the N-terminus and a R-X<sub>2-5</sub>