Sandbox 122: Difference between revisions

Karyopherin beta 2 (kapβ2) is an importin that transports various cargo protein into the nucleus through interactions :with nucleoporins,  which are proteins of the nucleopore complex (NPC). One might overlook the significance of this :protein but actually plays a crucial role in the human body by mediating transport of RNA- binding proteins involved in :transcription, RNA processing, RNA transport and translation. The structure of KAPβ is composed of  

<scene name='37/372723/4oo6_rainbow_heat_repeats/1'>20 antiparallel helices :</scene>called HEAT repeats. These HEAT repeats contribute to kapβ2’s large superhelical shape. That form two arches: one at the :N-terminal and the other at the C- terminal. Through recognition of a nuclear localization signal (NLS) located on its :cargo, kapβ2 binds to its cargo via its C-terminal arch. Release of the cargo is mediated by RanGTP, which once bound, :modifies the shape of kapβ2.  Release of the cargo is mediated once contact occurs between RanGTP and N-terminal arch of Kapβ2.