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==Crystal structure of C-terminal tudor domain in PcrA/UvrD helicase== | |||
<StructureSection load='5dma' size='340' side='right' caption='[[5dma]], [[Resolution|resolution]] 1.53Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5dma]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DMA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DMA FirstGlance]. <br> | |||
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dma OCA], [http://pdbe.org/5dma PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dma RCSB], [http://www.ebi.ac.uk/pdbsum/5dma PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dma ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PCRA_GEOSE PCRA_GEOSE]] DNA helicase. Has a broad nucleotide specificity, even being able to hydrolyze ethenonucleotides, and is able to couple the hydrolysis to unwinding of DNA substrates. It is a 3'-5' helicase but at high protein concentrations it can also displace a substrate with a 5' tail. Preferred substrate being one with both single and double-stranded regions of DNA. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: DNA helicase]] | |||
[[Category: Dillingham, M]] | [[Category: Dillingham, M]] | ||
[[Category: Lin, C L]] | |||
[[Category: Wigley, D]] | [[Category: Wigley, D]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: Pcra/uvrd helicase]] | |||
[[Category: Rna polymerase]] | |||
[[Category: Transcription]] | |||
[[Category: Tudor domain]] | |||
Revision as of 20:03, 3 October 2016
Crystal structure of C-terminal tudor domain in PcrA/UvrD helicaseCrystal structure of C-terminal tudor domain in PcrA/UvrD helicase
Structural highlights
Function[PCRA_GEOSE] DNA helicase. Has a broad nucleotide specificity, even being able to hydrolyze ethenonucleotides, and is able to couple the hydrolysis to unwinding of DNA substrates. It is a 3'-5' helicase but at high protein concentrations it can also displace a substrate with a 5' tail. Preferred substrate being one with both single and double-stranded regions of DNA. |
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