1k6f: Difference between revisions

Revision as of 22:21, 2 May 2008

Crystal Structure of the Collagen Triple Helix Model [(Pro-Pro-Gly)10]3

OverviewOverview

The first report of the full-length structure of the collagen-like polypeptide [(Pro-Pro-Gly)(10)](3) is given. This structure was obtained from crystals grown in a microgravity environment, which diffracted up to 1.3 A, using synchrotron radiation. The final model, which was refined to an R(factor) of 0.18, is the highest-resolution description of a collagen triple helix reported to date. This structure provides clues regarding a series of aspects related to collagen triple helix structure and assembly. The strict dependence of proline puckering on the position inside the Pro-Pro-Gly triplets and the correlation between backbone and side chain dihedral angles support the propensity-based mechanism of triple helix stabilization/destabilization induced by hydroxyproline. Furthermore, the analysis of [(Pro-Pro-Gly)(10)](3) packing, which is governed by electrostatic interactions, suggests that charges may act as locking features in the axial organization of triple helices in the collagen fibrils.

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the collagen triple helix model [(Pro-Pro-Gly)(10)](3)., Berisio R, Vitagliano L, Mazzarella L, Zagari A, Protein Sci. 2002 Feb;11(2):262-70. PMID:11790836 Page seeded by OCA on Fri May 2 22:21:44 2008

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OCA

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 [[Image:1k6f.jpg|left|200px]]
- {{Structure
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 '''Crystal Structure of the Collagen Triple Helix Model [(Pro-Pro-Gly)10]3'''
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 ==About this Structure==
-K6F is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6F OCA].
+Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6F OCA].
 ==Reference==
 Crystal structure of the collagen triple helix model [(Pro-Pro-Gly)(10)](3)., Berisio R, Vitagliano L, Mazzarella L, Zagari A, Protein Sci. 2002 Feb;11(2):262-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11790836 11790836]
-[[Category: Protein complex]]
 [[Category: Berisio, R.]]
 [[Category: Mazzarella, L.]]
 [[Category: Vitagliano, L.]]
 [[Category: Zagari, A]]
-[[Category: amino acid preference]]
+[[Category: Amino acid preference]]
-[[Category: collagen stability]]
+[[Category: Collagen stability]]
-[[Category: puckering]]
+[[Category: Puckering]]
-[[Category: triple helix,]]
+[[Category: Triple helix]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:21:44 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:44:03 2008''