5ewa: Difference between revisions

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==Crystal structure of the metallo-beta-lactamase IMP-1 in complex with the bisthiazolidine inhibitor L-VC26==
==Crystal structure of the metallo-beta-lactamase IMP-1 in complex with the bisthiazolidine inhibitor L-VC26==
<StructureSection load='5ewa' size='340' side='right' caption='[[5ewa]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5ewa' size='340' side='right'caption='[[5ewa]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ewa]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EWA FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ewa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EWA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EWA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9BZ:(3~{R},5~{R},7~{A}~{S})-2,2-DIMETHYL-5-(SULFANYLMETHYL)-3,5,7,7~{A}-TETRAHYDRO-[1,3]THIAZOLO[4,3-B][1,3]THIAZOLE-3-CARBOXYLIC+ACID'>9BZ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9BZ:(3~{R},5~{R},7~{A}~{S})-2,2-DIMETHYL-5-(SULFANYLMETHYL)-3,5,7,7~{A}-TETRAHYDRO-[1,3]THIAZOLO[4,3-B][1,3]THIAZOLE-3-CARBOXYLIC+ACID'>9BZ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ewa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ewa OCA], [http://pdbe.org/5ewa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ewa RCSB], [http://www.ebi.ac.uk/pdbsum/5ewa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ewa ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ewa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ewa OCA], [http://pdbe.org/5ewa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ewa RCSB], [http://www.ebi.ac.uk/pdbsum/5ewa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ewa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</div>
</div>
<div class="pdbe-citations 5ewa" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ewa" style="background-color:#fffaf0;"></div>
==See Also==
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Large Structures]]
[[Category: Hinchliffe, P]]
[[Category: Hinchliffe, P]]
[[Category: Kosmopoulou, M]]
[[Category: Kosmopoulou, M]]

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