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==Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly== | |||
<StructureSection load='5fjv' size='340' side='right' caption='[[5fjv]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5fjv]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FJV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FJV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPJ:EPIBATIDINE'>EPJ</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fjv OCA], [http://pdbe.org/5fjv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fjv RCSB], [http://www.ebi.ac.uk/pdbsum/5fjv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fjv ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/ACHA2_HUMAN ACHA2_HUMAN]] Autosomal dominant nocturnal frontal lobe epilepsy. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACHA2_HUMAN ACHA2_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Chroni-Tzartou, D]] | [[Category: Chroni-Tzartou, D]] | ||
[[Category: Giastas, P]] | [[Category: Giastas, P]] | ||
[[Category: Kouvatsos, N]] | [[Category: Kouvatsos, N]] | ||
[[Category: Tzartos, S | [[Category: Tzartos, S J]] | ||
[[Category: Acetylcholine-binding protein]] | |||
[[Category: Agonist]] | |||
[[Category: Alpha2]] | |||
[[Category: Epibatidine]] | |||
[[Category: Extracellular domain]] | |||
[[Category: Nachr]] | |||
[[Category: Nicotinic acetylcholine receptor]] | |||
Revision as of 19:24, 10 August 2016
Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assemblyCrystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly
Structural highlights
Disease[ACHA2_HUMAN] Autosomal dominant nocturnal frontal lobe epilepsy. The disease is caused by mutations affecting the gene represented in this entry. Function[ACHA2_HUMAN] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. |
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