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==Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A== | ==Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A== | ||
<StructureSection load='5bpv' size='340' side='right' caption='[[5bpv]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='5bpv' size='340' side='right'caption='[[5bpv]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5bpv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPV FirstGlance]. <br> | <table><tr><td colspan='2'>[[5bpv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Zebov Zebov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPV FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpv OCA], [http://pdbe.org/5bpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpv RCSB], [http://www.ebi.ac.uk/pdbsum/5bpv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpv ProSAT]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP35 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186538 ZEBOV])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpv OCA], [http://pdbe.org/5bpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bpv RCSB], [http://www.ebi.ac.uk/pdbsum/5bpv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bpv ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Zebov]] | |||
[[Category: Alcaro, S]] | [[Category: Alcaro, S]] | ||
[[Category: Bianco, G]] | [[Category: Bianco, G]] | ||
Revision as of 11:53, 11 March 2020
Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278ACrystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A
Structural highlights
Function[VP35_EBOZ5] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity). |
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