1jqp: Difference between revisions

Revision as of 21:40, 2 May 2008

dipeptidyl peptidase I (cathepsin C), a tetrameric cysteine protease of the papain family

OverviewOverview

The crystal structure of mature dipeptidyl peptidase I reveals insight into the unique tetrameric structure, substrate binding and activation of this atypical papain family peptidase. Each subunit is composed of three peptides. The heavy and light chains form the catalytic domain, which adopts the papain fold. The residual pro-part forms a beta-barrel with the carboxylate group of Asp1 pointing towards the substrate amino-terminus. The tetrameric structure appears to stabilize the association of the two domains and encloses a 12700 A3 spherical cavity. The tetramer contains six chloride ions, one buried in each S2 pocket and two at subunit interfaces.

About this StructureAbout this Structure

1JQP is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain., Olsen JG, Kadziola A, Lauritzen C, Pedersen J, Larsen S, Dahl SW, FEBS Lett. 2001 Oct 12;506(3):201-6. PMID:11602245 Page seeded by OCA on Fri May 2 21:40:51 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1jqp.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1jqp |SIZE=350|CAPTION= <scene name='initialview01'>1jqp</scene>, resolution 2.4&Aring;
+The line below this paragraph, containing "STRUCTURE_1jqp", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_I Dipeptidyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.1 3.4.14.1] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1jqp|  PDB=1jqp  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqp OCA], [http://www.ebi.ac.uk/pdbsum/1jqp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jqp RCSB]</span>
-}}
 '''dipeptidyl peptidase I (cathepsin C), a tetrameric cysteine protease of the papain family'''
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 [[Category: Olsen, J G.]]
 [[Category: Pedersen, J.]]
-[[Category: cathepsin c]]
+[[Category: Cathepsin c]]
-[[Category: chloride]]
+[[Category: Chloride]]
-[[Category: cysteine protease]]
+[[Category: Cysteine protease]]
-[[Category: dpp i]]
+[[Category: Dpp i]]
-[[Category: papain]]
+[[Category: Papain]]
-[[Category: tetramer]]
+[[Category: Tetramer]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 21:40:51 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:37:36 2008''