5lbt: Difference between revisions

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-'''Unreleased structure'''
-The entry 5lbt is ON HOLD
+==Structure of the human quinone reductase 2 (NQO2) in complex with imiquimod==
+<StructureSection load='5lbt' size='340' side='right' caption='[[5lbt]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-Authors: Schneider, S., Gross, O.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5lbt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LBT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LBT FirstGlance]. <br>
-Description: Structure of the human quinone reductase 2 (NQO2) in complex with imiquimod
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6T0:1-(2-METHYLPROPYL)IMIDAZO[4,5-C]QUINOLIN-4-AMINE'>6T0</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.5.1 1.10.5.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lbt OCA], [http://pdbe.org/5lbt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lbt RCSB], [http://www.ebi.ac.uk/pdbsum/5lbt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lbt ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Gross, O]]
 [[Category: Schneider, S]]
+[[Category: Oxidoreductase]]
+[[Category: Quinone reductase 2 ribosyldihydronicotinamide dehydrogenase]]