1ji4: Difference between revisions

Revision as of 21:15, 2 May 2008

NAP protein from helicobacter pylori

OverviewOverview

Helicobacter pylori is a major human pathogen associated with severe gastroduodenal diseases, including ulcers and cancers. An H.pylori protein that is highly immunogenic in humans and mice has been identified recently. This protein has been termed HP-NAP, due to its ability of activating neutrophils. In order to achieve a molecular understanding of its unique immunogenic and pro-inflammatory properties, we have determined its three-dimensional structure. Its quaternary structure is similar to that of the dodecameric bacterial ferritins (Dps-like family), but it has a different surface potential charge distribution. This is due to the presence of a large number of positively charged residues, which could well account for its unique ability in activating human leukocytes.

About this StructureAbout this Structure

1JI4 is a Single protein structure of sequence from Helicobacter pylori. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the neutrophil-activating protein from Helicobacter pylori., Zanotti G, Papinutto E, Dundon W, Battistutta R, Seveso M, Giudice G, Rappuoli R, Montecucco C, J Mol Biol. 2002 Oct 11;323(1):125-30. PMID:12368104 Page seeded by OCA on Fri May 2 21:15:05 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1ji4.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1ji4 |SIZE=350|CAPTION= <scene name='initialview01'>1ji4</scene>, resolution 2.52&Aring;
+The line below this paragraph, containing "STRUCTURE_1ji4", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= NAPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])
+-->
-|DOMAIN=
+{{STRUCTURE_1ji4|  PDB=1ji4  |  SCENE=  }}
-|RELATEDENTRY=[[1dps|1DPS]], [[1qgh|1QGH]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji4 OCA], [http://www.ebi.ac.uk/pdbsum/1ji4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ji4 RCSB]</span>
-}}
 '''NAP protein from helicobacter pylori'''
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 [[Category: Seveso, M.]]
 [[Category: Zanotti, G.]]
-[[Category: dodecamer]]
+[[Category: Dodecamer]]
-[[Category: four-helix bundle]]
+[[Category: Four-helix bundle]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 21:15:05 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:33:59 2008''