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'''Crystal structure of the APC10/Doc1 subunit of the human anaphase-promoting complex''' | '''Crystal structure of the APC10/Doc1 subunit of the human anaphase-promoting complex''' | ||
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[[Category: Vodermaier, H C.]] | [[Category: Vodermaier, H C.]] | ||
[[Category: Wendt, K S.]] | [[Category: Wendt, K S.]] | ||
[[Category: | [[Category: Beta sandwich]] | ||
[[Category: | [[Category: Jellyroll]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:13:49 2008'' | |||
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Revision as of 21:13, 2 May 2008
Crystal structure of the APC10/Doc1 subunit of the human anaphase-promoting complex
OverviewOverview
The anaphase-promoting complex (APC), or cyclosome, is a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC is composed of at least 11 subunits; no structure has been determined for any of these subunits. The subunit APC10/DOC1, a one-domain protein consisting of 185 amino acids, has a conserved core (residues 22-161) that is homologous to domains found in several other putative ubiquitin ligases and, therefore, may play a role in ubiquitination reactions. Here we report the crystal structure of human APC10 at 1.6 A resolution. The core of the protein is formed by a beta-sandwich that adopts a jellyroll fold. Unexpectedly, this structure is highly similar to ligand-binding domains of several bacterial and eukaryotic proteins, such as galactose oxidase and coagulation factor Va, raising the possibility that APC10 may function by binding a yet unidentified ligand. We further provide biochemical evidence that the C-terminus of APC10 binds to CDC27/APC3, an APC subunit that contains multiple tetratrico peptide repeats.
About this StructureAbout this Structure
1JHJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex., Wendt KS, Vodermaier HC, Jacob U, Gieffers C, Gmachl M, Peters JM, Huber R, Sondermann P, Nat Struct Biol. 2001 Sep;8(9):784-8. PMID:11524682 Page seeded by OCA on Fri May 2 21:13:49 2008