5i2f: Difference between revisions

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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BS5:5-DEOXY-5-[({5-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANOYL}SULFAMOYL)AMINO]ADENOSINE'>BS5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BS5:5-DEOXY-5-[({5-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANOYL}SULFAMOYL)AMINO]ADENOSINE'>BS5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tw2|3tw2]], [[4eqe|4eqe]], [[4eqg|4eqg]], [[4eqh|4eqh]], [[5i2e|5i2e]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tw2|3tw2]], [[4eqe|4eqe]], [[4eqg|4eqg]], [[4eqh|4eqh]], [[5i2e|5i2e]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2f OCA], [http://pdbe.org/5i2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i2f RCSB], [http://www.ebi.ac.uk/pdbsum/5i2f PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2f OCA], [http://pdbe.org/5i2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i2f RCSB], [http://www.ebi.ac.uk/pdbsum/5i2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==

Revision as of 05:27, 13 July 2016

Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) with bound sulfamide inhibitor Bio-AMSHuman Histidine Triad Nucleotide Binding Protein 1 (hHint1) with bound sulfamide inhibitor Bio-AMS

Structural highlights

5i2f is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[HINT1_HUMAN] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity).

5i2f, resolution 1.25Å

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OCA