Phosphocarrier protein: Difference between revisions
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<StructureSection load='1fu0' size='350' side='right' caption='Structure of phosphocarrier protein HPr (PDB entry [[1fu0]])' scene=''> | <StructureSection load='1fu0' size='350' side='right' caption='Structure of phosphocarrier protein HPr (PDB entry [[1fu0]])' scene=''> | ||
== Function == | |||
'''Phosphocarrier protein HPr''' (HPr) is a component of the sugar phosphotransferase system. The system catalyses the phosphorylation of sugars during their translocation across cell membrane. A phosphoryl group is transferred from phosphoenolpyruvate via several enzymes (EI, EII) to HPr<ref>PMID:8246840</ref>. A conserved histidine in the N terminal of HPr is the acceptor of the phosphate. In Gram-positive bacteria HPr there is a conserved serine which is phosphorylated. | '''Phosphocarrier protein HPr''' (HPr) is a component of the sugar phosphotransferase system. The system catalyses the phosphorylation of sugars during their translocation across cell membrane. A phosphoryl group is transferred from phosphoenolpyruvate via several enzymes (EI, EII) to HPr<ref>PMID:8246840</ref>. A conserved histidine in the N terminal of HPr is the acceptor of the phosphate. In Gram-positive bacteria HPr there is a conserved serine which is phosphorylated. | ||
== Structural highlights == | |||
The phosphorylation of Ser46 prohibits the HPr to act as a phosphocarrier in the EI reaction<ref>PMID:11054290</ref>. | |||
</StructureSection> | </StructureSection> | ||