5fyn: Difference between revisions
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<table><tr><td colspan='2'>[[5fyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FYN FirstGlance]. <br> | <table><tr><td colspan='2'>[[5fyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FYN FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fyn OCA], [http://pdbe.org/5fyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fyn RCSB], [http://www.ebi.ac.uk/pdbsum/5fyn PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fyn OCA], [http://pdbe.org/5fyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fyn RCSB], [http://www.ebi.ac.uk/pdbsum/5fyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fyn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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Revision as of 06:53, 30 August 2017
Sub-tomogram averaging of Tula virus glycoprotein spikeSub-tomogram averaging of Tula virus glycoprotein spike
Structural highlights
Publication Abstract from PubMedHantaviruses, a geographically diverse group of zoonotic pathogens, initiate cell infection through the concerted action of Gn and Gc viral surface glycoproteins. Here, we describe the high-resolution crystal structure of the antigenic ectodomain of Gn from Puumala hantavirus (PUUV), a causative agent of hemorrhagic fever with renal syndrome. Fitting of PUUV Gn into an electron cryomicroscopy reconstruction of intact Gn-Gc spike complexes from the closely related but non-pathogenic Tula hantavirus localized Gn tetramers to the membrane-distal surface of the virion. The accuracy of the fitting was corroborated by epitope mapping and genetic analysis of available PUUV sequences. Interestingly, Gn exhibits greater non-synonymous sequence diversity than the less accessible Gc, supporting a role of the host humoral immune response in exerting selective pressure on the virus surface. The fold of PUUV Gn is likely to be widely conserved across hantaviruses. A Molecular-Level Account of the Antigenic Hantaviral Surface.,Li S, Rissanen I, Zeltina A, Hepojoki J, Raghwani J, Harlos K, Pybus OG, Huiskonen JT, Bowden TA Cell Rep. 2016 May 3;15(5):959-67. doi: 10.1016/j.celrep.2016.03.082. Epub 2016, Apr 21. PMID:27117403[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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