1j9j: Difference between revisions

Revision as of 20:57, 2 May 2008

CRYSTAL STRUCTURE ANALYSIS OF SURE PROTEIN FROM T.MARITIMA

OverviewOverview

Homologs of the Escherichia coli surE gene are present in many eubacteria and archaea. Despite the evolutionary conservation, little information is available on the structure and function of their gene products. We have determined the crystal structure of the SurE protein from Thermotoga maritima. The structure reveals the dimeric arrangement of the subunits and an active site around a bound metal ion. We also demonstrate that the SurE protein exhibits a divalent metal ion-dependent phosphatase activity that is inhibited by vanadate or tungstate. In the vanadate- and tungstate-complexed structures, the inhibitors bind adjacent to the divalent metal ion. Our structural and functional analyses identify the SurE proteins as a novel family of metal ion-dependent phosphatases.

About this StructureAbout this Structure

1J9J is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family., Lee JY, Kwak JE, Moon J, Eom SH, Liong EC, Pedelacq JD, Berendzen J, Suh SW, Nat Struct Biol. 2001 Sep;8(9):789-94. PMID:11524683 Page seeded by OCA on Fri May 2 20:57:00 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1j9j.jpg|left|200px]]
- {{Structure
+<!--
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+The line below this paragraph, containing "STRUCTURE_1j9j", creates the "Structure Box" on the page.
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+You may change the PDB parameter (which sets the PDB file loaded into the applet)
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+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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-|GENE=
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-|DOMAIN=
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-|RELATEDENTRY=[[1j9k|1J9K]], [[1j9l|1J9L]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j9j OCA], [http://www.ebi.ac.uk/pdbsum/1j9j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j9j RCSB]</span>
-}}
 '''CRYSTAL STRUCTURE ANALYSIS OF SURE PROTEIN FROM T.MARITIMA'''
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 [[Category: Moon, J.]]
 [[Category: Suh, S W.]]
-[[Category: sure protein]]
+[[Category: Sure protein]]
-[[Category: thermotoga maritima]]
+[[Category: Thermotoga maritima]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:57:00 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:30:28 2008''