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==Crystal Structure of COMT in complex with 2,4-dimethyl-5-[3-(1-phenylethyl)-1H-pyrazol-5-yl]-1,3-thiazole== | |||
<StructureSection load='5k0b' size='340' side='right' caption='[[5k0b]], [[Resolution|resolution]] 2.36Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5k0b]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K0B FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PS:2,4-DIMETHYL-5-{3-[(1R)-1-PHENYLETHYL]-1H-PYRAZOL-5-YL}-1,3-THIAZOLE'>6PS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k0b OCA], [http://pdbe.org/5k0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k0b RCSB], [http://www.ebi.ac.uk/pdbsum/5k0b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k0b ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Catechol O-methyltransferase]] | |||
[[Category: Ehler, A]] | [[Category: Ehler, A]] | ||
[[Category: | [[Category: RODRIGUEZ-SARMIENTO, R M]] | ||
[[Category: Rudolph, M | [[Category: Rudolph, M G]] | ||
[[Category: Catechol]] | |||
[[Category: Methyltransferase]] | |||
[[Category: Neurotransmitter degradation]] | |||
[[Category: Transferase]] | |||
Revision as of 00:10, 11 September 2016
Crystal Structure of COMT in complex with 2,4-dimethyl-5-[3-(1-phenylethyl)-1H-pyrazol-5-yl]-1,3-thiazoleCrystal Structure of COMT in complex with 2,4-dimethyl-5-[3-(1-phenylethyl)-1H-pyrazol-5-yl]-1,3-thiazole
Structural highlights
Function[COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. |
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