1is3: Difference between revisions

Revision as of 20:20, 2 May 2008

LACTOSE AND MES-LIGANDED CONGERIN II

OverviewOverview

The crystal structure of congerin II, a galectin family lectin from conger eel, was determined at 1.45A resolution. The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however, the structure of congerin II described here resembles other prototype galectins. A comparison of the two congerin genes with that of several other galectins suggests acceralated evolution of both congerin genes following gene duplication. The presence of a Mes (2-[N-morpholino]ethanesulfonic acid) molecule near the carbohydrate-binding site in the crystal structure points to the possibility of an additional binding site in congerin II. The binding site consists of a group of residues that had been replaced following gene duplication suggesting that the binding site was built under selective pressure. Congerin II may be a protein specialized for biological defense with an affinity for target carbohydrates on parasites' cell surface.

About this StructureAbout this Structure

1IS3 is a Single protein structure of sequence from Conger myriaster. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of a conger eel galectin (congerin II) at 1.45A resolution: implication for the accelerated evolution of a new ligand-binding site following gene duplication., Shirai T, Matsui Y, Shionyu-Mitsuyama C, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K, J Mol Biol. 2002 Aug 30;321(5):879-89. PMID:12206768 Page seeded by OCA on Fri May 2 20:20:53 2008

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OCA

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 [[Image:1is3.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1is3 |SIZE=350|CAPTION= <scene name='initialview01'>1is3</scene>, resolution 1.45&Aring;
+The line below this paragraph, containing "STRUCTURE_1is3", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=LAT:LACTOSE'>LAT</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1is3|  PDB=1is3  |  SCENE=  }}
-|RELATEDENTRY=[[1c1l|1C1L]], [[1is4|1IS4]], [[1is5|1IS5]], [[1is6|1IS6]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1is3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1is3 OCA], [http://www.ebi.ac.uk/pdbsum/1is3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1is3 RCSB]</span>
-}}
 '''LACTOSE AND MES-LIGANDED CONGERIN II'''
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 [[Category: Shirai, T.]]
 [[Category: Yamane, T.]]
-[[Category: complex with lactose and me]]
+[[Category: Complex with lactose and me]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:20:53 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:23:54 2008''