2bwf: Difference between revisions
New page: left|200px<br /> <applet load="2bwf" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bwf, resolution 1.15Å" /> '''CRYSTAL STURCTURE O... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
2BWF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with FMT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BWF OCA]]. | 2BWF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with FMT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BWF OCA]]. | ||
==Reference== | ==Reference== | ||
| Line 27: | Line 27: | ||
[[Category: ubiquitin]] | [[Category: ubiquitin]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:04:30 2007'' | ||
Revision as of 11:59, 30 October 2007
|
CRYSTAL STURCTURE OF THE UBL DOMAIN OF DSK2 FROM S. CEREVISIAE
OverviewOverview
The yeast proteins Dsk2 and Rad23 belong to a family of proteins that, contain an N-terminal ubiquitin-like domain (UBL) and a C-terminal, ubiquitin-associated domain (UBA). Both Dsk2 and Rad23 function as, adaptors to target ubiquitin-labelled proteins to the proteasome through, recognition of polyubiquitin (four or more K48-linked ubiquitins) by their, UBA domains and to the yeast proteasomal subunit Rpn1 by their UBL, domains. The crystal structures of the Dsk2 UBL domain, the Dsk2 UBA, domain and the Dsk2 UBA-UBL complex are reported. In the crystal, the Dsk2, UBA domains associate through electrostatic interactions to form ninefold, helical ribbons that leave the ubiquitin-binding surface exposed. The, UBA-UBL complex explains the reduced affinity of the UBA domain for UBL, compared ... [(full description)]
About this StructureAbout this Structure
2BWF is a [Single protein] structure of sequence from [Saccharomyces cerevisiae] with FMT as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structures of the Dsk2 UBL and UBA domains and their complex., Lowe ED, Hasan N, Trempe JF, Fonso L, Noble ME, Endicott JA, Johnson LN, Brown NR, Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):177-88. Epub 2006, Jan 18. PMID:16421449
Page seeded by OCA on Tue Oct 30 11:04:30 2007