5jo3: Difference between revisions
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==PDE5A for NaV1.7== | |||
<StructureSection load='5jo3' size='340' side='right' caption='[[5jo3]], [[Resolution|resolution]] 1.49Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jo3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JO3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JO3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6LK:1-(5-CHLORO-6-METHOXYPYRIDIN-3-YL)-3-METHYL-N-(METHYLSULFONYL)-1H-INDAZOLE-5-CARBOXAMIDE'>6LK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jo3 OCA], [http://pdbe.org/5jo3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jo3 RCSB], [http://www.ebi.ac.uk/pdbsum/5jo3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jo3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: 3',5'-cyclic-GMP phosphodiesterase]] | |||
[[Category: Chrencik, J]] | |||
[[Category: Storer, I]] | |||
[[Category: Hydrolase]] | |||
Revision as of 16:08, 4 May 2017
PDE5A for NaV1.7PDE5A for NaV1.7
Structural highlights
Function[PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. |
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