1iod: Difference between revisions

Revision as of 20:13, 2 May 2008

CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE COAGULATION FACTOR X BINDING PROTEIN FROM SNAKE VENOM AND THE GLA DOMAIN OF FACTOR X

OverviewOverview

The gamma-carboxyglutamic acid (Gla) domain of blood coagulation factors is responsible for Ca2+-dependent phospholipid membrane binding. Factor X-binding protein (X-bp), an anticoagulant protein from snake venom, specifically binds to the Gla domain of factor X. The crystal structure of X-bp in complex with the Gla domain peptide of factor X at 2.3-A resolution showed that the anticoagulation is based on the fact that two patches of the Gla domain essential for membrane binding are buried in the complex formation. The Gla domain thus is expected to be a new target of anticoagulant drugs, and X-bp provides a basis for designing them. This structure also provides a membrane-bound model of factor X.

About this StructureAbout this Structure

1IOD is a Single protein structure of sequence from Bos taurus and Deinagkistrodon acutus. The following page contains interesting information on the relation of 1IOD with [Tissue Factor]. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of an anticoagulant protein in complex with the Gla domain of factor X., Mizuno H, Fujimoto Z, Atoda H, Morita T, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7230-4. Epub 2001 Jun 12. PMID:11404471 Page seeded by OCA on Fri May 2 20:13:08 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1iod.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1iod |SIZE=350|CAPTION= <scene name='initialview01'>1iod</scene>, resolution 2.3&Aring;
+The line below this paragraph, containing "STRUCTURE_1iod", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1iod|  PDB=1iod  |  SCENE=  }}
-|RELATEDENTRY=[[1ixx|1IXX]], [[1bj3|1BJ3]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iod OCA], [http://www.ebi.ac.uk/pdbsum/1iod PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1iod RCSB]</span>
-}}
 '''CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE COAGULATION FACTOR X BINDING PROTEIN FROM SNAKE VENOM AND THE GLA DOMAIN OF FACTOR X'''
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 [[Category: Mizuno, H.]]
 [[Category: Morita, T.]]
-[[Category: calcium bridging]]
+[[Category: Calcium bridging]]
-[[Category: domain swapping]]
+[[Category: Domain swapping]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:13:08 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:22:31 2008''