1ih4: Difference between revisions

Revision as of 19:59, 2 May 2008

Multi-Conformation Crystal Structure of GGm5CGCC

OverviewOverview

The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:11390969 Page seeded by OCA on Fri May 2 19:59:37 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1ih4.gif|left|200px]]
- {{Structure
+<!--
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+The line below this paragraph, containing "STRUCTURE_1ih4", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=5CM:5-METHYL-2&#39;-DEOXY-CYTIDINE-5&#39;-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1ih4|  PDB=1ih4  |  SCENE=  }}
-|RELATEDENTRY=[[1ih1|1IH1]], [[1ih2|1IH2]], [[1ih3|1IH3]], [[1ih6|1IH6]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ih4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ih4 OCA], [http://www.ebi.ac.uk/pdbsum/1ih4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ih4 RCSB]</span>
-}}
 '''Multi-Conformation Crystal Structure of GGm5CGCC'''
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 ==About this Structure==
-IH4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH4 OCA].
+Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH4 OCA].
 ==Reference==
 A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11390969 11390969]
-[[Category: Protein complex]]
 [[Category: Henderson, K.]]
 [[Category: Ho, P S.]]
 [[Category: Vargason, J M.]]
-[[Category: b to a dna transition]]
+[[Category: B to a dna transition]]
-[[Category: dna transition]]
+[[Category: Dna transition]]
-[[Category: structural transition]]
+[[Category: Structural transition]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:59:37 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:19:42 2008''