5hfd: Difference between revisions

Revision as of 19:27, 18 January 2017

The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)

Structural highlights

5hfd is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1bfe, 5hdy, 5heb, 5hed, 5het, 5hey, 5hf1, 5hf4, 5hfb, 5hfc, 5hfe, 5hff
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.^[1] ^[2]

References

↑ Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem. 2004 Nov 5;279(45):46962-8. Epub 2004 Aug 17. PMID:15317815 doi:10.1074/jbc.M405874200
↑ Prange O, Wong TP, Gerrow K, Wang YT, El-Husseini A. A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13915-20. Epub 2004 Sep 9. PMID:15358863 doi:10.1073/pnas.0405939101

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OCA

[1] Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem. 2004 Nov 5;279(45):46962-8. Epub 2004 Aug 17. PMID:15317815 doi:10.1074/jbc.M405874200

[2] Prange O, Wong TP, Gerrow K, Wang YT, El-Husseini A. A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13915-20. Epub 2004 Sep 9. PMID:15358863 doi:10.1073/pnas.0405939101

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5hfd is ON HOLD  until Paper Publication
+==The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)==
+<StructureSection load='5hfd' size='340' side='right' caption='[[5hfd]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5hfd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HFD FirstGlance]. <br>
-Description:
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bfe|1bfe]], [[5hdy|5hdy]], [[5heb|5heb]], [[5hed|5hed]], [[5het|5het]], [[5hey|5hey]], [[5hf1|5hf1]], [[5hf4|5hf4]], [[5hfb|5hfb]], [[5hfc|5hfc]], [[5hfe|5hfe]], [[5hff|5hff]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfd OCA], [http://pdbe.org/5hfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hfd RCSB], [http://www.ebi.ac.uk/pdbsum/5hfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Raman, A S]]
+[[Category: Ranganathan, R]]
+[[Category: White, K I]]
+[[Category: Adhesion]]
+[[Category: Dhr]]
+[[Category: Glgf]]
+[[Category: Pdz]]
+[[Category: Peptide binding protein]]
+[[Category: Peptide-binding domain]]
+[[Category: Synapse]]
+[[Category: Synaptic density]]

5hfd: Difference between revisions

Revision as of 19:27, 18 January 2017

The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)

Structural highlights

Function

References

Contents

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5hfd: Difference between revisions

Revision as of 19:27, 18 January 2017

The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)

Structural highlights

Function

References

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