5f60: Difference between revisions

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-'''Unreleased structure'''
-The entry 5f60 is ON HOLD  until Paper Publication
+==Crystal structure of the first bromodomain of human BRD4 in complex with SG3-014==
+<StructureSection load='5f60' size='340' side='right' caption='[[5f60]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5f60]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F60 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5VZ:~{N}-[2-CHLORANYL-5-[[5-METHYL-2-[[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO]PYRIMIDIN-4-YL]AMINO]PHENYL]-2-METHYL-PROPANE-2-SULFONAMIDE'>5VZ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f5z|5f5z]], [[5f61|5f61]], [[5f62|5f62]], [[5f63|5f63]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f60 OCA], [http://pdbe.org/5f60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f60 RCSB], [http://www.ebi.ac.uk/pdbsum/5f60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f60 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ember, S W]]
+[[Category: Schonbrunn, E]]
+[[Category: Zhu, J Y]]
+[[Category: Bromodomain]]
+[[Category: Cap]]
+[[Category: Cell cycle]]
+[[Category: Hunk1]]
+[[Category: Inhibitor]]
+[[Category: Mcap]]
+[[Category: Mitotic chromosome associated protein]]
+[[Category: Protein binding-inhibitor complex]]
+[[Category: Transcription-inhibitor complex]]
+[[Category: Transcription-transcription inhibitor complex]]