1iap: Difference between revisions

Revision as of 19:46, 2 May 2008

CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN

OverviewOverview

p115RhoGEF, a guanine nucleotide exchange factor for Rho GTPase, is also a GTPase activating protein (GAP) for G(12) and G(13) heterotrimeric G alpha subunits. Near its N-terminus, p115RhoGEF contains a domain (rgRGS) with remote sequence identity to RGS (regulators of G protein signaling) domains. The rgRGS domain is necessary but not sufficient for the GAP activity of p115RhoGEF. The 1.9 A resolution crystal structure of the rgRGS domain shows structural similarity to RGS domains but possesses a C-terminal extension that folds into a layer of helices that pack against the hydrophobic core of the domain. Mutagenesis experiments show that rgRGS may form interactions with G alpha(13) that are analogous to those in complexes of RGS proteins with their G alpha substrates.

About this StructureAbout this Structure

1IAP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the rgRGS domain of p115RhoGEF., Chen Z, Wells CD, Sternweis PC, Sprang SR, Nat Struct Biol. 2001 Sep;8(9):805-9. PMID:11524686 Page seeded by OCA on Fri May 2 19:46:40 2008

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OCA

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 '''CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN'''
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-[[Category: rg]]
+[[Category: Rg]]
-[[Category: rhogef]]
+[[Category: Rhogef]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:46:40 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:02 2008''