1ia9: Difference between revisions

Revision as of 19:45, 2 May 2008

CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (AMPPNP COMPLEX)

OverviewOverview

Transient receptor potential (TRP) channels modulate calcium levels in eukaryotic cells in response to external signals. A novel transient receptor potential channel has the ability to phosphorylate itself and other proteins on serine and threonine residues. The catalytic domain of this channel kinase has no detectable sequence similarity to classical eukaryotic protein kinases and is essential for channel function. The structure of the kinase domain, reported here, reveals unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains. The inclusion of the channel kinase catalytic domain within the eukaryotic protein kinase superfamily indicates a significantly wider distribution for this group of signaling proteins than suggested previously by sequence comparisons alone.

About this StructureAbout this Structure

1IA9 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity., Yamaguchi H, Matsushita M, Nairn AC, Kuriyan J, Mol Cell. 2001 May;7(5):1047-57. PMID:11389851 Page seeded by OCA on Fri May 2 19:45:58 2008

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OCA

@@ Line 1: / Line 1: @@
 [[Image:1ia9.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1ia9 |SIZE=350|CAPTION= <scene name='initialview01'>1ia9</scene>, resolution 2.0&Aring;
+The line below this paragraph, containing "STRUCTURE_1ia9", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= CHAK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+-->
-|DOMAIN=
+{{STRUCTURE_1ia9|  PDB=1ia9  |  SCENE=  }}
-|RELATEDENTRY=[[1iah|1IAH]], [[1iaj|1IAJ]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ia9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ia9 OCA], [http://www.ebi.ac.uk/pdbsum/1ia9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ia9 RCSB]</span>
-}}
 '''CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (AMPPNP COMPLEX)'''
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 [[Category: Nairn, A C.]]
 [[Category: Yamaguchi, H.]]
-[[Category: alpha/beta]]
+[[Category: Alpha/beta]]
-[[Category: atp-grasp fold]]
+[[Category: Atp-grasp fold]]
-[[Category: protein kinase like fold]]
+[[Category: Protein kinase like fold]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:45:58 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:16:51 2008''