5j5o: Difference between revisions
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==Translation initiation factor 4E in complex with m7GppppG mRNA 5' cap analog== | |||
<StructureSection load='5j5o' size='340' side='right' caption='[[5j5o]], [[Resolution|resolution]] 1.87Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5j5o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J5O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J5O FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6G0:5-O-[(R)-HYDROXY{[(R)-HYDROXY{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]OXY}PHOSPHORYL]-7-METHYLGUANOSINE'>6G0</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j5o OCA], [http://pdbe.org/5j5o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j5o RCSB], [http://www.ebi.ac.uk/pdbsum/5j5o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j5o ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/IF4E_MOUSE IF4E_MOUSE]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:18805096</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Jemielity, J]] | [[Category: Jemielity, J]] | ||
[[Category: Kowalska, J]] | |||
[[Category: Nowak, E]] | [[Category: Nowak, E]] | ||
[[Category: Nowotny, M]] | [[Category: Nowotny, M]] | ||
[[Category: Rydzik, A M]] | |||
[[Category: Warminski, M]] | [[Category: Warminski, M]] | ||
[[Category: Eif4e]] | |||
[[Category: M7gppppg]] | |||
[[Category: Mrna 5' cap analog]] | |||
[[Category: Protein-ligand complex]] | |||
[[Category: Translation]] | |||
[[Category: Translation initiation factor]] | |||
Revision as of 15:55, 10 May 2017
Translation initiation factor 4E in complex with m7GppppG mRNA 5' cap analogTranslation initiation factor 4E in complex with m7GppppG mRNA 5' cap analog
Structural highlights
Function[IF4E_MOUSE] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.[1] References
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