1htp: Difference between revisions

Revision as of 19:13, 2 May 2008

REFINED STRUCTURES AT 2 ANGSTROMS AND 2.2 ANGSTROMS OF THE TWO FORMS OF THE H-PROTEIN, A LIPOAMIDE-CONTAINING PROTEIN OF THE GLYCINE DECARBOXYLASE COMPLEX

OverviewOverview

Glycine decarboxylase consists of four protein components. Its structural and mechanistic heart is provided by the lipoic acid-containing H-protein which undergoes a cycle of reductive methylamination, methylamine transfer and electron transfer. Lipoic acid attached to a specific lysine side chain is assumed to act as a 'swinging arm' conveying the reactive dithiolane ring from one catalytic centre to another. The X-ray crystal structures of two forms of the H-protein have been determined. The lipoate cofactor is located in the loop of a hairpin configuration but following methylamine transfer it is pivoted to bind into a cleft at the surface of the H-protein. The lipoamide-methylamine arm is, therefore, not free to move in aqueous solvent.

About this StructureAbout this Structure

1HTP is a Single protein structure of sequence from Pisum sativum. Full crystallographic information is available from OCA.

ReferenceReference

The lipoamide arm in the glycine decarboxylase complex is not freely swinging., Cohen-Addad C, Pares S, Sieker L, Neuburger M, Douce R, Nat Struct Biol. 1995 Jan;2(1):63-8. PMID:7719855 Page seeded by OCA on Fri May 2 19:13:13 2008

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OCA

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 [[Image:1htp.gif|left|200px]]
- {{Structure
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-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_dehydrogenase_(decarboxylating) Glycine dehydrogenase (decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.4.2 1.4.4.2] </span>
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htp OCA], [http://www.ebi.ac.uk/pdbsum/1htp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1htp RCSB]</span>
-}}
 '''REFINED STRUCTURES AT 2 ANGSTROMS AND 2.2 ANGSTROMS OF THE TWO FORMS OF THE H-PROTEIN, A LIPOAMIDE-CONTAINING PROTEIN OF THE GLYCINE DECARBOXYLASE COMPLEX'''
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 ==Reference==
 The lipoamide arm in the glycine decarboxylase complex is not freely swinging., Cohen-Addad C, Pares S, Sieker L, Neuburger M, Douce R, Nat Struct Biol. 1995 Jan;2(1):63-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7719855 7719855]
-[[Category: Glycine dehydrogenase (decarboxylating)]]
 [[Category: Pisum sativum]]
 [[Category: Single protein]]
 [[Category: Cohen-Addad, C.]]
 [[Category: Pares, S.]]
-[[Category: oxidoreductases(acting on ch-nh2 donor)]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:13:13 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:10:16 2008''