5ego: Difference between revisions

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-'''Unreleased structure'''
-The entry 5ego is ON HOLD  until Paper Publication
+==HOXB13-MEIS1 heterodimer bound to methylated DNA==
+<StructureSection load='5ego' size='340' side='right' caption='[[5ego]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
-Authors: Morgunova, E., Yin, Y., Jolma, A., Popov, A., Taipale, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ego]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EGO FirstGlance]. <br>
-Description: HOXB13-MEIS1 heterodimer bound to methylated DNA
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ego FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ego OCA], [http://pdbe.org/5ego PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ego RCSB], [http://www.ebi.ac.uk/pdbsum/5ego PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ego ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/MEIS1_HUMAN MEIS1_HUMAN]] Disease susceptibility may be associated with variations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/HXB13_HUMAN HXB13_HUMAN]] Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. [[http://www.uniprot.org/uniprot/MEIS1_HUMAN MEIS1_HUMAN]] Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.<ref>PMID:12609849</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Jolma, A]]
+[[Category: Morgunova, E]]
 [[Category: Popov, A]]
-[[Category: Jolma, A]]
+[[Category: Taipale, J]]
 [[Category: Yin, Y]]
-[[Category: Taipale, J]]
+[[Category: Bound to dna]]
-[[Category: Morgunova, E]]
+[[Category: Complex]]
+[[Category: Heterodimer]]
+[[Category: Transcription]]
+[[Category: Transcription factor]]