1hla: Difference between revisions

Revision as of 18:58, 2 May 2008

STRUCTURE OF THE HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN, HLA-A2

OverviewOverview

The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight antiparallel beta-strands topped by alpha-helices. A large groove between the alpha-helices provides a binding site for processed foreign antigens. An unknown 'antigen' is found in this site in crystals of purified HLA-A2.

About this StructureAbout this Structure

1HLA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the human class I histocompatibility antigen, HLA-A2., Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC, Nature. 1987 Oct 8-14;329(6139):506-12. PMID:3309677 Page seeded by OCA on Fri May 2 18:58:35 2008

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OCA

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 [[Category: Strominger, J L.]]
 [[Category: Wiley, D C.]]
-[[Category: histocompatibility antigen]]
+[[Category: Histocompatibility antigen]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:58:35 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:07:10 2008''