Sandbox WWC2: Difference between revisions
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== Disease == | == Disease == | ||
Due to the important role MAO-A plays in maintaining a balance of various neurotransmitters in the digestive and central nervous system, as well as its production of ROS, an imbalance of MAO-A may result in any of several diseases. For example, postpartum depression is a moderate to severe form of depression that occurs as the result of an excess of MAO-A in the brain that some women experience after childbirth, often referred to as the baby blues [http://www.mpg.de].In research conducted by Julia Sacher of the Max Planck Institute for Human Cognitive and Brain Sciences, it was concluded that the levels of MAO-A in women with postpartum depression are about 40% greater than those of average women. [[Image:Postpardam_depression_maoa.jpg|thumb|right|”Positron-Emission-Tomography (PET) of a depressive patient without medication (left) with elevated monoamine-oxidase-A-levels (green, yellow, red) and after a six-week-treatment with the monoamine-oxidase-A-inhibitor moclobemid (right)” [https://www.mpg.de/8331073/postpartum-depression_monoamine-oxidase-a]]. | Due to the important role MAO-A plays in maintaining a balance of various neurotransmitters in the digestive and central nervous system, as well as its production of ROS, an imbalance of MAO-A may result in any of several diseases. For example, postpartum depression is a moderate to severe form of depression that occurs as the result of an excess of MAO-A in the brain that some women experience after childbirth, often referred to as the baby blues [http://www.mpg.de].In research conducted by Julia Sacher of the Max Planck Institute for Human Cognitive and Brain Sciences, it was concluded that the levels of MAO-A in women with postpartum depression are about 40% greater than those of average women. [[Image:Postpardam_depression_maoa.jpg|thumb|right|”Positron-Emission-Tomography (PET) of a depressive patient without medication (left) with elevated monoamine-oxidase-A-levels (green, yellow, red) and after a six-week-treatment with the monoamine-oxidase-A-inhibitor moclobemid (right)” [https://www.mpg.de/8331073/postpartum-depression_monoamine-oxidase-a]]]. | ||
Brunner's syndrome (BRUNS) is a disease associated with a mutation in the MAOA gene that results in a deficiency of MAO-A and as a result causes mind mental retardation and aggressive behavior in males. Females heterzygotes for this mutation exhibit no mental retardation or aggressive behavior [https://ghr.nlm.nih.gov/gene/MAOA#conditions]. | Brunner's syndrome (BRUNS) is a disease associated with a mutation in the MAOA gene that results in a deficiency of MAO-A and as a result causes mind mental retardation and aggressive behavior in males. Females heterzygotes for this mutation exhibit no mental retardation or aggressive behavior [https://ghr.nlm.nih.gov/gene/MAOA#conditions]. | ||