Metabotropic glutamate receptor: Difference between revisions
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[[Metabotropic glutamate receptor|Metabotropic glutamate receptors]] are [[Glutamate Receptors|glutamate receptors]] that activate ion channels indirectly through a signaling cascade involving G proteins<ref>PMID:20716669</ref>. They are members of the large class of seven-transmembrane domain receptors, the [[G protein-coupled receptor|G protein-coupled receptors]]. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also [[Ligand Binding N-Terminal of Metabotropic Glutamate Receptors]]. | [[Metabotropic glutamate receptor|Metabotropic glutamate receptors]] are [[Glutamate Receptors|glutamate receptors]] that activate ion channels indirectly through a signaling cascade involving G proteins<ref>PMID:20716669</ref>. They are members of the large class of seven-transmembrane domain receptors, the [[G protein-coupled receptor|G protein-coupled receptors]]. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also [[Ligand Binding N-Terminal of Metabotropic Glutamate Receptors]]. | ||
*'''Metabotropic glutamate receptor 1''' and '''metabotropic glutamate receptor 5''' belong to group I and activate phospholipase C.<br /> | *'''Metabotropic glutamate receptor 1''' and '''metabotropic glutamate receptor 5''' belong to group I and activate phospholipase C. For details see [[Metabotropic glutamate receptor 5]].<br /> | ||
*'''Metabotropic glutamate receptor 2''' and '''metabotropic glutamate receptor 3''' belong to group II and inhibit the cyclic AMP cascade.<br /> | *'''Metabotropic glutamate receptor 2''' and '''metabotropic glutamate receptor 3''' belong to group II and inhibit the cyclic AMP cascade.<br /> | ||
*'''Metabotropic glutamate receptor 7''' belongs to group III and inhibits adenylate cyclase activity.<br /> | *'''Metabotropic glutamate receptor 7''' belongs to group III and inhibits adenylate cyclase activity.<br /> | ||