Matrix metalloproteinase: Difference between revisions
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== Function == | == Function == | ||
'''Matrix metalloproteinases''' (MMP) are Zinc-dependent endopeptidases. MMP degrades extracellular matrix proteins. They are inhibited by proteases called tissue inhibitors of metalloproteinase (TIMP). The pro-MMP contains a pro-peptide which must be removed to render the MMP active<ref>PMID:10419448</ref>. See details in<br /> | '''Matrix metalloproteinases''' (MMP) are Zinc-dependent endopeptidases. MMP degrades extracellular matrix proteins. They are inhibited by proteases called tissue inhibitors of metalloproteinase (TIMP). The pro-MMP contains a pro-peptide which must be removed to render the MMP active<ref>PMID:10419448</ref>. See details in<br /> | ||
* [[Matrix metalloproteinases]]<br /> | * [[Matrix metalloproteinases]]<br /> | ||
* [[Metalloproteases]]<br /> | * [[Metalloproteases]]<br /> | ||
* [[MT1-MMP-TIMP-1 complex]]<br />. | * [[MT1-MMP-TIMP-1 complex]]<br />. | ||
MMPs are produced by 28 different genes and are classified according to their protein substrates.<br /> | MMPs are produced by 28 different genes and are classified according to their protein substrates.<br /> | ||
* MMP1 cleaves collagens I, II, III, VII and X.<br /> | * '''MMP1''' cleaves collagens I, II, III, VII and X.<br /> | ||
* MMP2 cleaves collagen IV and denatured collagen.<br /> | * '''MMP2''' cleaves collagen IV and denatured collagen.<br /> | ||
* MMP3 cleaves the core protein of aggrecan and plasminogen activator.<br /> | * '''MMP3''' cleaves the core protein of aggrecan and plasminogen activator.<br /> | ||
* MMP7 cleaves proteoglycans, fibronectin, elastin and casein.<br /> | * '''MMP7''' cleaves proteoglycans, fibronectin, elastin and casein.<br /> | ||
* MMP8 cleaves aggrecan.<br /> | * '''MMP8''' cleaves aggrecan.<br /> | ||
* MMP9 cleaves gelatin. See details in [[Molecular Playground/MMP9]]<br /> | * '''MMP9''' cleaves gelatin. See details in [[Molecular Playground/MMP9]]<br /> | ||
* MMP10 cleaves collagens III, IV, V, fibronectin,gelatin and aggrecan.<br /> | * '''MMP10''' cleaves collagens III, IV, V, fibronectin,gelatin and aggrecan.<br /> | ||
* MMP11 cleaves peptides in human tumors.<br /> | * '''MMP11''' cleaves peptides in human tumors.<br /> | ||
* MMP12 cleaves collagens I and III. See details in [[Matrix Metalloproteinase 12]] <br /> | * '''MMP12''' cleaves collagens I and III. See details in [[Matrix Metalloproteinase 12]] <br /> | ||
* MMP13 cleaves collagen II and laminin-5 γ2.<br /> | * '''MMP13''' cleaves collagen II and laminin-5 γ2.<br /> | ||
* MMP14 is a membrane-type MMP which cleaves aggrecan. See details in [[Molecular Playground/MMP14]]<br /> | * '''MMP14''' is a membrane-type MMP which cleaves aggrecan. See details in [[Molecular Playground/MMP14]]<br /> | ||
* '''MMP16''' cleaves collagen III, proteoglycans, fibronectin, gelatin, vitronectin, laminin and α2-macroglobulin.<br /> | |||
* '''MMP20''' cleaves E-cadherin.<br /> | |||
* '''MMP23''' function is unknown.<br /> | |||
* '''MMP adamalysin''' is a snake toxin. See details in [[Atragin]]<br /> | |||
== Relevance == | == Relevance == | ||