Matrix metalloproteinase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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 == Function ==
-'''Matrix metalloproteinases''' (MMP) are Zinc-dependent endopeptidases.  MMP degrades extracellular matrix proteins.  MMPs are produced by 28 different genes and are classified according to their protein substrates.  They are inhibited by proteases called tissue inhibitors of metalloproteinase (TIMP).  The pro-MMP contains a pro-peptide which must be removed to render the MMP active<ref>PMID:10419448</ref>. See details in<br />
+'''Matrix metalloproteinases''' (MMP) are Zinc-dependent endopeptidases.  MMP degrades extracellular matrix proteins.  They are inhibited by proteases called tissue inhibitors of metalloproteinase (TIMP).  The pro-MMP contains a pro-peptide which must be removed to render the MMP active<ref>PMID:10419448</ref>. See details in<br />
 * [[Matrix Metalloproteinase 12]]<br />
 * [[Molecular Playground/MMP9]]<br />
-* [[Molecular Playground/MMP14]]<br />
+* [[Molecular Playground/MMP9]]<br />
 * [[Matrix metalloproteinases]]<br />
 * [[Metalloproteases]]<br />
 * [[Atragin]] for MMP adamalysin<br />
 * [[MT1-MMP-TIMP-1 complex]]<br />.
+MMPs are produced by 28 different genes and are classified according to their protein substrates.<br />
+* MMP1 cleaves collagens I, II, III, VII and X.<br />
+* MMP2 cleaves collagen IV and denatured collagen.<br />
+* MMP3 cleaves the core protein of aggrecan and plasminogen activator.<br />
+* MMP7 cleaves proteoglycans, fibronectin, elastin and casein.<br />
+* MMP8 cleaves aggrecan.<br />
+* MMP9 cleaves gelatin.  See details in [[Molecular Playground/MMP9]]<br />
+* MMP10 cleaves collagens III, IV, V, fibronectin,gelatin and aggrecan.<br />
+* MMP11 cleaves peptides in human tumors.<br />
+* MMP12 cleaves collagens I and III. See details in [[Matrix Metalloproteinase 12]] <br />
+* MMP13 cleaves collagen II and laminin-5 γ2.<br />
+* MMP14 is a membrane-type MMP which cleaves aggrecan.  See details in [[Molecular Playground/MMP14]]<br />
 == Relevance ==
-MMPs have a role in cancer progression<ref>PMID:21087457</ref>.  MMP-8, MMP-9, MMP-13 and MMP-14 have a role in periodontal diseases<ref>PMID:8315570</ref>.
+MMPs have a role in cancer progression<ref>PMID:21087457</ref>.  MMP-2 and MMP-9 secretion is elevated in ovarian cancer and are associated with poor prognosis<ref>PMID:19360311</ref>.  MMP-8, MMP-9, MMP-13 and MMP-14 have a role in periodontal diseases<ref>PMID:8315570</ref>.
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