Leukocyte immunoglobulin-like receptor: Difference between revisions

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*LIR-1
*LIR-1


**[[1g0x]], [[1ufu]] – hLIR ligand-binding domain D1D2– human <br />
**[[1g0x]], [[1ufu]] – hLIR-1 ligand-binding domain D1D2– human <br />
**[[1ugn]], [[1vdg]] – hLIR ligand-binding domain D1D2 (mutant) <br />
**[[1ugn]], [[1vdg]] – hLIR-1 ligand-binding domain D1D2 (mutant) <br />
**[[4ll9]] – hLIR ligand-binding domain D3D4 <br />
**[[4ll9]] – hLIR-1 ligand-binding domain D3D4 <br />
 
*LIR-2
 
**[[4lla]] – hLIR-2 ligand-binding domain D3D4 <br />
**[[2otp]] – hLIR-2 ligand-binding domain D1D2 <br />
**[[2dyp]] – hLIR-2 ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  H2A peptide<br />
 
*LIR-4
 
**[[3q2c]] – hLIR-4 N-terminal domain  <br />
 
*LIR-5
 
**[[3p2t]] – hLIR-5 ligand-binding domain D1D2 <br />


*LIR-1 complexes
*LIR-1 complexes


**[[1p7q]] – hLIR ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  POL polyprotein peptide<br />
**[[1p7q]] – hLIR-1 ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  POL polyprotein peptide<br />
**[[3d2u]] – hLIR ligand-binding domain D1D2 + herpesvirus UL18 + β-2 microglobulin +  actin peptide<br />
**[[5knm]] – hLIR-1 ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  peptide<br />
**[[4no0]] – hLIR-1 ligand-binding domain D1D2 + class I MHC + β-2 microglobulin +  lymphocyte-specific protein peptide<br />
**[[3d2u]] – hLIR-1 ligand-binding domain D1D2 + herpesvirus UL18 + β-2 microglobulin +  actin peptide<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:04, 4 July 2017


Leukocyte immunoglobulin-like receptors (LIR) or CD85 have extracellular immunoglobulin domains. LIR modulates a variety of immune cells. LIR interacts with class I MHC molecules[1].

Structure of human leukocyte immunoglobulin-like receptor ligand-binding domain (yellow) complex with class I MHC (grey), β-2 microglobulin (green) and POL polyprotein peptide (pink) (PDB entry 1p7q)

Drag the structure with the mouse to rotate

3D structures of leukocyte immunoglobulin-like receptor3D structures of leukocyte immunoglobulin-like receptor

Updated on 04-July-2017

ReferencesReferences

  1. Thomas R, Matthias T, Witte T. Leukocyte immunoglobulin-like receptors as new players in autoimmunity. Clin Rev Allergy Immunol. 2010 Apr;38(2-3):159-62. doi:, 10.1007/s12016-009-8148-8. PMID:19548123 doi:http://dx.doi.org/10.1007/s12016-009-8148-8

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman