Sandbox Reserved 426: Difference between revisions

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OCA, Lynmarie K Thompson, Student, Arash Manafirad, Allison Coutu

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	==Additional Features==		==Additional Features==
	In <scene name='48/483883/Mikescene/1'>this depiction</scene>, one can see that the anthraquinone derivative is located between the backbones and base pairs of DNA. The drug is squeezed or intercalated between the nucleotides shown in red. In the human body, the nucleotide in gold would also be interacting with the drug shown in black, but in order for this complex to be studied, a short segment of DNA had to be used. Consequently the gold nucleotide is involved in abnormal molecular interactions and is out of place. This intercalation interrupts the function of taq polymerase and telomerase. Taq polymerase is in part responsible for the replication of DNA and consequently, cell replication. Telomeres are repeating sections of non-coding DNA that protect the ends of coding sections of DNA from degradation. Each time a cell divides, telomeres shorten. Over time, telomeres shorten to the point of disappearance, causing DNA degradation and cell death. Telomerase builds up these protective sections of DNA. Cancer is characterized as an uncontrolled rate of cell growth. By inhibiting the replication DNA and the construction of protective telomeres, this drug serves to slow and stop cancerous cell growth.		In <scene name='48/483883/Mikescene/1'>this depiction</scene>, one can see that the anthraquinone derivative is located between the backbones and base pairs of DNA. The drug is squeezed or intercalated between the nucleotides <scene name='48/483883/Mikescene/3'>shown in red</scene>. In the human body, the <scene name='48/483883/Mikescene/2'>nucleotide in gold</scene> would also be interacting with the drug shown in black, but in order for this complex to be studied, a short segment of DNA had to be used. Consequently the gold nucleotide is involved in abnormal molecular interactions and is out of place. This intercalation interrupts the function of taq polymerase and telomerase. Taq polymerase is in part responsible for the replication of DNA and consequently, cell replication. Telomeres are repeating sections of non-coding DNA that protect the ends of coding sections of DNA from degradation. Each time a cell divides, telomeres shorten. Over time, telomeres shorten to the point of disappearance, causing DNA degradation and cell death. Telomerase builds up these protective sections of DNA. Cancer is characterized as an uncontrolled rate of cell growth. By inhibiting the replication DNA and the construction of protective telomeres, this drug serves to slow and stop cancerous cell growth.